Abstract: From the transnational perspective and the new politic history, this article analyses the pathway of chilean socialism as from the reception and appropiation made on Guatemala's revolution and counter revolution between 1944 and 1959. In this regard, we state that the reception, resignification and appropiation of the guatemaltecan process became another input in the reconfiguration of its third-position populism as it enhaced its antinorthamerican and latinoamerican component, and with it, contributed to the decline of anti-sovietism and anti-comunism sentiment that once destinguished it. In this regard, we affirm that the reception of the guatemaltecan process constitued one more element in the blending of its populist conception along with marxism. In this investigative line, through the review of parliamentary speeches, magazines, newspapers and official party documents, we demonstrate the contribution of the guatemaltecan cicle on the multicausality of factors that articulated the politic reconfiguration of chilean socialism's populist concept.

Resumen: Desde la perspectiva transnacional y la nueva historia política, el presente artículo analiza la trayectoria del socialismo chileno a partir de la recepción y apropiación realizada de la revolución y contrarrevolución en Guatemala, entre 1944 y 1959. Al respecto, afirmamos que la recepción, resignificación y apropiación del proceso guatemalteco se convirtió en un insumo más en la reconfiguración de su populismo tercerposicionista, en tanto, acentuó sus componentes antinorteamericanos y latinoamericanistas, y con ello, contribuyó a la disminución del antisovietismo y el anticomunismo que otrora le habían caracterizado. En ese sentido, sostenemos que la recepción del proceso guatemalteco constituyó un elemento más en el proceso de hibridación de su concepción populista con el marxismo. En esa línea, a través de la revisión de discursos parlamentarios, revistas, diarios y documentos oficiales partidarios, damos cuenta del aporte del ciclo guatemalteco en la multicausalidad de factores que se articularon en la reconfiguración política de la concepción populista del socialismo chileno.

SUMMARY OBJECTIVE: The aim of this study was to measure the reliability, internal consistency, and construct validity of the Kidney Symptom Questionnaire for the Brazilian population. METHODS: This is a cross-cultural adaptation and questionnaire validation study. We included native Brazilians of both sex aged>18 years, as well as hypertensive and/or diabetic patients. All participants were assessed using Screening for Occult Renal Disease, EuroQol 5 Dimensions, 36-Item Short Form Survey, and the Kidney Symptom Questionnaire. We used Spearman’s coefficient (rho) to measure the correlations between the Kidney Symptom Questionnaire and other instruments; Cronbach’s alpha to measure internal consistency; and intraclass correlation coefficient, standard error of measurement, and minimum detectable change to measure test-retest reliability. RESULTS: The sample was formed by 121 adult participants, mostly female, with systemic arterial hypertension and/or diabetes mellitus. We found excellent reliability (intraclass correlation coefficient≥0.978), adequate internal consistency (Cronbach’s alpha≥0.860), and adequate construct validity on the Kidney Symptom Questionnaire domains; besides, we observed significant correlations between the Kidney Symptom Questionnaire and other instruments. CONCLUSION: The Brazilian version of the Kidney Symptom Questionnaire has adequate measurement properties to assess chronic/occult kidney disease in patients who do not require renal replacement therapy.

ABSTRACT In the Cerrado, the palm swamps ( veredas ) are characterized by being humid and stable environments that lead to the formation of Histosols ( Organossolos ). and soils with surface horizons of organic constitution, which are fragile and sensitive to anthropic action. This study aimed to evaluate the impact of anthropization (recurrent forest fires and livestock farming) on the chemical, physical and morphological properties of soils in two palm swamps in the Environmental Preservation Area (EPA) of Pandeiros River, Minas Gerais, namely: Água Doce, in preserved condition, and Taboa, in anthropized condition. Four soil profiles were morphologically described, two profiles in each palm swamp, with subsequent chemical and physical analyses, calculations of organic carbon stock and identification of the origin of organic matter. The results were analyzed using descriptive statistics and Pearson’s correlation coefficient. Soil morphological properties were influenced by vegetation cover, drainage and anthropization conditions. As for the physical and chemical properties, adequate values were observed in the preserved palm swamp, including lower bulk density values and higher cation contents. Anthropic actions in the anthropized palm swamp caused degradation of soils, revealed by subsidence, reduction in organic carbon content, increase in bulk density and decrease in fertility. Changes promoted in the soils of the palm swamps compromise ecosystem services, indicating that actions at either local or governmental level should be stimulated for the preservation and conservation of these environments.

BACKGROUND Leishmaniasis, a neglected disease caused by the parasite Leishmania, is treated with drugs associated with high toxicity and limited efficacy, in addition to constant reports of the emergence of resistant parasites. In this context, snake serums emerge as good candidates since they are natural sources with the potential to yield novel drugs. OBJECTIVES We aimed to show the antileishmanial effects of γCdcPLI, a phospholipase A2 inhibitor from Crotalus durissus collilineatus snake serum, against Leishmania (Leishmania) amazonensis. METHODS Promastigotes forms were exposed to γCdcPLI, and we assessed the parasite viability and cell cycle, as well as invasion and proliferation assays. FINDINGS Despite the low cytotoxicity effect on macrophages, our data indicate that γCdcPLI has a direct effect on parasites promoting an arrest in the G1 phase and reduction in the G2/M phase at the highest dose tested. Moreover, this PLA2 inhibitor reduced the parasite infectivity when promastigotes were pre-treated. Also, we demonstrated that the γCdcPLI treatment modulated the host cell environment impairing early and late steps of the parasitism. MAIN CONCLUSIONS γCdcPLI is an interesting tool for the discovery of new essential targets on the parasite, as well as an alternative compound to improve the effectiveness of the leishmaniasis treatment. Leishmaniasis efficacy context A serum (Leishmania amazonensis cycle assays macrophages G G2M GM G2 M tested Moreover PLA pretreated. pretreated pre treated. pre-treated Also parasitism

RESUMO Objetivo: Localizada em São Paulo, a Cracolândia é o maior e mais antigo cenário aberto de uso de drogas do Brasil. Ainda assim, pouco se sabe sobre o perfil dos indivíduos que vivem nessa região e buscam tratamento para crack . O objetivo deste estudo transversal foi descrever características demográficas e clínicas de usuários de crack vivendo na região da Cracolândia que estão em busca de tratamento. Métodos: Noventa e oito indivíduos foram avaliados para transtornos por uso de substâncias do DSM-V, padrão de uso de substâncias, impulsividade e sintomatologia psiquiátrica. O uso recente de crack também foi determinado por meio de coleta de amostras toxicológicas. Resultados: Os resultados indicaram grave vulnerabilidade social, com significativas prevalências de falta de moradia (46,9%), moradia instável (50%), desemprego (60,4%) e abandono escolar precoce (27,5%). A idade média de início do uso de crack foi de 20 anos (DP = 6,9) e a duração média do uso contínuo do crack foi de 15 anos (DP = 9,7). A maioria dos participantes apresentou alguma comorbidade psiquiátrica, particularmente transtorno por uso de álcool (87,8%), bem como altas taxas de sintomatologia psiquiátrica e impulsividade. Mais da metade da amostra relatou pelo menos uma tentativa anterior de tratamento por internação (73,5%) e ambulatorial (65,3%). Conclusão: Os achados desse estudo permitem um maior entendimento do perfil e das necessidades de usuários de crack vivendo na região da Cracolândia e podem ajudar serviços de saúde especializados em dependência química a promoverem uma assistência mais direcionada às demandas específicas dessa população.

ABSTRACT Objective: São Paulo‘s Crackland is the biggest and oldest open drug use scene in Brazil, yet little is known about the profile of crack cocaine treatment-seeking individuals living in this region. The aim of this crossectional study was to describe the demographics and clinical characteristics of treatment-seeking crack users living in the Crackland region. Methods: A sample of nighty eight individuals were screened for DSM-V substance use disorders, including substance use, impulsiveness, and psychiatric symptoms. Recent crack cocaine use was also tested using biologic specimens. Results: Results indicated severe social vulnerability, as participants experienced high rates of homelessness (46.9%), unstable housing (50%), unemployment (60.4%) and early school drop-out (27.5%). The average age of crack use onset was 20 years (SD = 6.9) and the mean duration of continuous crack use was 15 years (SD = 9.7). Most participants presented with concomitant mental health disorders, particularly alcohol use disorder (87.8%), as well high rates of psychiatric symptomatology and impulsiveness. More than half of the sample reported at least one previous inpatient (73.5%) and outpatient (65.3%) addiction treatment attempt. Conclusion: This population profile should inform mental healthcare services, promoting the provision of tailored assistance by targeting specific demands at all levels of treatment.

ABSTRACT Background: American cutaneous leishmaniasis is a commonly neglected, vector-borne tropical parasitic disease that is a major public health concern in Brazil. Leishmania (Viannia) braziliensis is the main species associated with the disease. Accurate diagnosis is based on epidemiological surveillance, clinical assessment, and laboratory testing. Leishmania (V.) braziliensis has been detected in several wild and synanthropic mammals. Their epidemiological role has not been entirely elucidated. This study aimed to assess potential L. braziliensis infections in asymptomatic domestic animals, by molecular and serological testing in endemic areas, in the metropolitan region of Recife. Methods: Blood samples and conjunctival fluids were collected from 232 animals (canids, felids, equines, and caprines) for the detection of L. braziliensis using molecular tests (conventional and real-time polymerase chain reaction [PCR and qPCR]). For immunological detection, blood samples from 115 dogs were assessed using enzyme-linked immunosorbent assay. Results: Real-time quantitative PCR showed positive results for blood and conjunctival samples in all investigated species. The results of the blood and conjunctival samples were 68.2% and 26.9% in Canis familiaris, 100% and 41.7% in Felis catus, 77.3% and 30.8% in Equus caballus/Equus asinus, and 50% and 33.3% in Capra hircus samples, respectively. Conclusions: Results from this study adds valuable information to our understanding of the role of asymptomatic domestic animals, L. braziliensis life cycle, and American cutaneous leishmaniasis in Northeast Brazil.

Aim This study aimed to analyze the influence of finishing and polishing (F/P) protocols on resin surface through roughness (Ra) values and laser scan microscopy observations. Methods Forty-eight (n=48) resin specimens were sorted into four groups (n=12), according to the type of resin used: Filtek Z250 (Z250), Filtek Z350 (Z350), Filtek One Bulk Fill (BF), Filtek P60 (P60). The specimens were sorted into six groups according to the type of F/P system used (n=2/group): Control group, Diamond bur (KG Sorensen), Soflex Pop-On Discs (3M ESPE), Soflex Spiral (3M ESPE), Dura Gloss (American Burs), and Praxis (TDV). Results The highest roughness values (Ra) were attributed to BF group for all F/P systems, except for the Soft-Lex PopOn discs. The Soft-Lex PopOn, Spiral, and Praxis discs presented a better performance for the surface treatment of the tested composite resins. Regardless of the restorative material, the use of diamond bur or single-step abrasive rubber (Dura Gloss) were associated with the highest Ra values. Conclusion The effect of F/P systems on Ra is material-dependent and instrument or system-dependent.

OBJECTIVES: To identify the clinical discriminative value and determinants of arterial stiffness in individuals with type 2 diabetes mellitus (T2DM). METHODS: This prospective cohort study included 51 individuals (53.57±9.35 years) diagnosed with T2DM (stage glucose≥126 mg/dL; diagnostic time: 87.4±69.8 months). All participants underwent an initial evaluation of personal habits, medications, and history; arterial stiffness assessment by carotid-femoral pulse wave velocity (cfPWV) using SphygmoCor; and blood laboratory analysis. A statistical analysis was performed using SPSS software, and values of p≤0.05 were considered significant. RESULTS: A cut-off cfPWV value of 7.9 m/s was identified for T2DM [Sensitivity (SE): 90% and Specificity (SP): 80%]. A subgroup analysis revealed higher glycated hemoglobin (Hb1Ac) (p=0.006), obesity (p=0.036), and dyslipidemia (p=0.013) than those with cfPWV ≥7.9 m/s. Multivariate analysis identified higher stage glucose (p=0.04), Hb1Ac (p=0.04), hypertension (p=0.001), and dyslipidemia (p=0.01) as determinant factors of cfPWV; positive and significant correlation between cfPWV and glucose (r=0.62; p=0.0003) and Hb1Ac (r=0.55; p=0.0031). CONCLUSIONS: In T2DM, an indicator of the discriminative value of arterial stiffness was cfPWV of 7.9 m/s. Clinical findings and comorbidities, such as hypertension, glucose, poor glycemic control, and dyslipidemia, were associated with and were determinants of arterial stiffness in T2DM. Reinforcement of monitoring risk factors, such as hypertension, dyslipidemia, and glycemic control, seems to be essential to the process of arterial stiffening. Confirmation of this discriminative value in larger populations is recommended.

Abstract The aim of this work was to analyze the properties and shear bond strength (SBS) of lithium disilicate to resin cement before and after etching the glass-ceramic surfaces. Lithium-metasilicate samples were heat treated and characterized by Scanning Electron Microscopy, X-ray diffraction and roughness measurement. For the analysis of the shear bonding strength (SBS) of lithium disilicate to dental resin cement, three groups (n = 12) of Li2Si2O5 were prepared: 1°)without treatment (NT); 2°)surface etching with hydrofluoric acid(HF), followed by silane agent and adhesive treatment; 3°) surface treatment with a self-etching ceramic primer (SECP). After the heat-treatment, the samples had Li2Si2O5 crystalline phase dispersed in a residual amorphous phase. Roughness of the NT and SECP samples was smaller that of the HF samples. Samples without surface treatment (NT) had the lowest SBS (5.5MPa). HF(24.2MPa) and SECP(24.8MPa) samples has similar SBS. Weibull statistics showed that HF-samples are more reliable than NT and SECP. The SBS was significantly increased by either HF etching and SECP surface treatment. While the chemical characteristics of the surface submitted to SECP treatment are considered to be responsible for the SBS increase, the main adhesion mechanism after HF etching is the increase in surface roughness.

RESUMO O objetivo deste estudo foi analisar as características e os determinantes da comunalidade na liquidez no mercado acionário brasileiro. Desde a internacionalização do mercado acionário brasileiro (Bolsa, Brasil, Balcão - B3), o fluxo de investimentos estrangeiros no Brasil aumentou ao longo dos anos, exceto em tempos de crise. Assim, o presente estudo argumenta que, no mercado acionário brasileiro, a comunalidade na liquidez é parcialmente determinada pelas negociações dos investidores estrangeiros. Apesar dos benefícios obtidos com recursos estrangeiros em nosso mercado acionário, é importante analisar o efeito do fluxo desses recursos nesse mercado. Este artigo contribui para a literatura atual ao fornecer evidências da comunalidade na liquidez no mercado acionário brasileiro e ao mostrar seu efeito mais forte em períodos de declínio de mercado. Portanto, os investidores deverão ter maior atenção sobre o risco de comunalidade nas suas carteiras, ao executarem ordens e, também, ao momento de realização das suas negociações, em virtude do aumento do custo de transação dos papéis mais sensíveis à comunalidade na liquidez. A amostra do estudo consistiu em um conjunto de empresas listadas na B3, de janeiro de 2007 a dezembro de 2017. Para analisar a comunalidade na liquidez, utilizamos o modelo proposto por Karolyi, Lee e Djik (2012) e por Qian, Tam e Zhang (2014). Para medir a influência de investidores estrangeiros no mercado acionário brasileiro, utilizamos três medidas baseadas em Gonçalves e Eid (2016). Os resultados mostraram que a comunalidade ocorre no mercado acionário brasileiro e que ela atinge picos durante as crises financeiras internacionais, além de indicar que a comunalidade pode ser maior em tempos de crise, devido às restrições de capital. Ademais, os resultados mostraram que a participação de investidores estrangeiros determinou parcialmente a comunalidade.

ABSTRACT The aim of this study was to analyze the characteristics and determinants of commonality in liquidity in the Brazilian stock market. Since the internationalization of the Brazilian stock market (Bolsa, Brasil, Balcão - B3), the flow of foreign investment in Brazil has increased over the years, except in times of crisis. Thus, the present study argues that, in the Brazilian stock market, commonality in liquidity is partly determined by foreign investor trading. Despite the benefits obtained from foreign resources in the Brazilian stock market, it is important to analyze the effect of this flow of foreign investment into the Brazilian stock market. This paper contributes to the current literature by providing evidence for commonality in liquidity in the Brazilian stock market and by showing its stronger effect in periods of market decline. Therefore, investors pay greater attention to the risk of commonality in their portfolios when executing orders and to their trading timing due to the increase in transaction costs of the stocks most sensitive to commonality in liquidity. The study sample consisted of a set of companies listed on the Brazilian stock exchange from January 2007 through December 2017. To analyze commonality in liquidity, we used the model proposed by Karolyi, Lee, and Djik (2012) and by Qian, Tam, and Zhang (2014). To measure the influence of foreign investors on the Brazilian stock market, we used three measures based on Gonçalves and Eid (2016). The results showed that commonality occurs in the Brazilian stock market and that it peaks during international financial crises, as well as indicated that commonality might be higher in times of crisis due to capital constraint. In addition, the results showed that foreign investor participation partly determined commonality.

Abstract Incidental thymic lesion findings have increased. An adequate characterization of these lesions in positron emission computed tomography (PET-CT) is essential, since it is used as part of most oncological planning procedures. Representative cases have been selected regarding the most important aspects of thymus imaging in PET-CT and how this technique can contribute to an accurate diagnosis or treatment planning. Specifically, we present a general description of common thymic lesions and disease mimics, with an emphasis on PET-CT findings, also incorporating examples of magnetic resonance imaging.

Resumen La pesquisa incidental de lesiones tímicas ha aumentado. Una adecuada aproximación a esas lesiones en la tomografía computada por emisión de positrones (PET-CT) es fundamental, pues se usa como parte de la mayoría de los procedimientos de planificación oncológica. Se han seleccionado casos representativos respecto de los aspectos más importantes de las imágenes de timo en PET-CT y cómo esa técnica puede contribuir a un diagnóstico preciso o a la planificación del tratamiento. Específicamente, presentamos una descripción general de las lesiones tímicas comunes y los imitadores de enfermedad, con énfasis en los hallazgos en PET-CT, incorporando también ejemplos de resonancia magnética (RM).

RESUMO Desde o surgimento da COVID-19, causada pelo coronavírus da Síndrome Respiratória Aguda Grave 2 (SARS-CoV-2), inúmeras medidas restritivas foram adotadas pelos governos de diferentes países. O retorno ao atendimento odontológico eletivo no Brasil uma realidade mesmo durante a pandemia do COVID-19. Durante procedimentos odontológicos restauradores, o profissional de odontologia requer contato próximo com o paciente, sendo exposto a saliva e outros contaminantes. Além disso, a transmissão de COVID-19 pela geração de aerossol produzido por peças de mão odontológicas pode ser possível. Assim, a equipe odontológica deve saber agir em durante o procedimento restaurador, colocando em prática os protocolos clínicos corretos para evitar a contaminação cruzada e a disseminação do COVID-19. O objetivo deste artigo é revisar a literatura sobre as práticas de biossegurança, especialmente no contexto de procedimentos odontológicos restauradores em tempo de COVID-19.

ABSTRACT Since the outbreak of the Coronavirus Disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), numerous restrictive measures have been adopted by governments of different countries. The return to elective dental care in Brazil is a reality even during the COVID-19 pandemic. During restorative dental procedures, the dental professional requires close contact with the patient, being exposed to contaminated saliva and fluids. In addition, transmission of COVID-19 by the generation of aerosol produced by dental handipieces may be possible. Thus, the dental staff must know how to act during restorative dental procedures, putting into practice the correct clinical protocols to avoid cross-contamination and COVID-19 spread. The purpose of this article is to review the literature on the biosafety practices especially in the context of restorative dental procedures in times of COVID-19.

Resumen:Esta propuesta de investigación, problematiza la historia de la izquierda chilena a partir de una perspectiva transnacional, poniendo énfasis en la recepción y resignificación de procesos políticos latinoamericanos desarrollados entre la década del cincuenta y sesenta del siglo pasado. Al respecto, planteamos que la construcción programática de la izquierda y su proyecto de “vía chilena al socialismo”, se vio permeada y alimentada por debates, experiencias y formulaciones políticas emanadas desde otras latitudes del continente. Así, las diversas recepciones de estos procesos políticos por parte de la izquierda chilena, se convirtieron en importantes insumos de discusión en torno a problemáticas vinculadas al carácter de la revolución y la construcción programática y estratégica.

Abstract:This research proposal, problematizes the history of the Chilean Left from a transnational perspective, emphasizing the reception and resignification of Latin-American political processes developed between the fifties and sixties of last century. About this matter, we conceive that the programmatic construction of the left and its project of the “Chilean path towards socialism”, was permeated and nourished by debates, experiences and political formulations emanated from other latitudes of the continent. Thus, the diverse receptions of these political processes in the Chilean left, became important instruments for the discussion around problematics linked to the character of the revolution and strategic and programmatic construction.

Abstract: Many sick leaves are rejected by causal medical order without expressing sufficiently the reasons to do so. Protection remedies have submitted pretending to declare illegal and arbitrary these pronouncements, with disparate results, laying contradictory criteria with each other, even in a Court of Appeals. Through the study of judicial and administrative jurisprudence, it is intended to establish a basic standard to explain or motivate these rejections, in order to ensure respect for the fundamental rights of the sick people.

Resumen: Muchas licencias médicas son rechazadas por causales de orden médico sin expresar suficientemente las razones para ello. Varios recursos de protección se han presentado pretendiendo declarar arbitrarios e ilegales estos pronunciamientos, con dispares resultados, sentando criterios contradictorios entre sí, aun en una misma Corte de Apelaciones. A través del estudio de la jurisprudencia judicial y administrativa, se pretende establecer un estándar básico para fundamentar o motivar estos rechazos, a fin de garantizar el respeto de los derechos fundamentales de la población enferma.

Objective: To investigate the prevalence of early childhood maltreatment and associations with later sexual behavior among adult substance users. Methods: A cross-sectional study enrolled 134 substance dependents who sought outpatient care in São Paulo, Brazil. Childhood trauma prevalence was assessed using the Childhood Trauma Questionnaire (CTQ). The Sexual Addiction Screening Test (SAST), drug of choice (DOC), and sexual behavior were also investigated. Results: The sample was composed predominantly of single adult males (76.1%), with alcohol as the DOC (73.9%). Experiences of emotional neglect (88.1%), emotional abuse (80.6%), physical neglect (78.4%), physical abuse (64.2%), and sexual abuse (31.3%) were prevalent. Women were more likely to have been sexually abused (OR 2.9, 95%CI 1.15-7.61) and physically abused (OR 3.7, 95%CI 1.31-10.6) in childhood. Those who were sexually abused in adulthood were more likely to have suffered physical abuse in childhood (OR 6.9, 95%CI 1.45-11.8). The odds of having been sexually abused in childhood were higher among subjects who reported to have exchanged sexual favors for drugs (OR 5.7, 95%CI 1.35-9.64) and to have been sexually abused in adulthood (OR 6.1, 95%CI 5.2-12.36). Conclusion: Physical and sexual abuse in childhood are highly prevalent in substance-dependent adults, and are associated with sexual revictimization and high-risk sexual behavior in adulthood.